Meyer, Hemmo:
p97 complexes as signal integration hubs
In: BMC Biology (incorporating Journal of Biology), Band 10 (2012), S. 48
2012Artikel/Aufsatz in ZeitschriftOA Gold
BiologieMedizinForschungszentren » Zentrum für Medizinische Biotechnologie (ZMB)
Damit verbunden: 1 Publikation(en)
Titel in Englisch:
p97 complexes as signal integration hubs
Autor*in:
Meyer, HemmoUDE
GND
1089446616
LSF ID
51479
ORCID
0000-0003-1883-1796ORCID iD
Sonstiges
der Hochschule zugeordnete*r Autor*in
Erscheinungsjahr:
2012
Open Access?:
OA Gold
DuEPublico 1 ID
Scopus ID
Notiz:
OA Förderung 2012
Sprache des Textes:
Englisch

Abstract:

In the ubiquitin-proteasome system, a subset of ubiquitylated proteins requires the AAA+ ATPase p97 (also known as VCP or Cdc48) for extraction from membranes or protein complexes before delivery to the proteasome for degradation. Diverse ubiquitin adapters are known to link p97 to its client proteins, but two recent papers on the adapter protein UBXD7, including one by Bandau et al. in BMC Biology, suggest that rather than simply linking p97 to ubiquitylated proteins, this adapter may be essential to coordinate ubiquitylation and p97-mediated extraction of the proteasome substrate. These findings add to growing indications of richly diverse roles of adapters in p97-mediated signaling functions