HTRA proteases: regulated proteolysis in protein quality control

In: Nature Reviews, Molecular Cell Biology, Jg. 12 (2011) ; Nr. 3, S. 152-162
ISSN: 1471-0072
Zeitschriftenaufsatz / Fach: Biologie
Controlled proteolysis underlies a vast diversity of protective and regulatory processes that are of key importance to cell fate. The unique molecular architecture of the widely conserved high temperature requirement A (HTRA) proteases has evolved to mediate critical aspects of ATP-independent protein quality control. The simple combination of a classic Ser protease domain and a carboxy-terminal peptide-binding domain produces cellular factors of remarkable structural and functional plasticity that allow cells to rapidly respond to the presence of misfolded or mislocalized polypeptides.