Meyer, Hemmo; Kondo, Hisao; Warren, Graham:
The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97
1998
In: FEBS letters : the journal for rapid publication of short reports in molecular biosciences, Jg. 437 (1998), Heft 3, S. 255 - 257
Artikel/Aufsatz in Zeitschrift / Fach: Biologie
Titel:
The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97
Autor(in):
Meyer, Hemmo im Online-Personal- und -Vorlesungsverzeichnis LSF anzeigen; Kondo, Hisao; Warren, Graham
Erscheinungsjahr:
1998
Erschienen in:
FEBS letters : the journal for rapid publication of short reports in molecular biosciences, Jg. 437 (1998), Heft 3, S. 255 - 257
ISSN:
Signatur der UB:
Link URL:

Abstract:

The highly conserved ATPase p97, a member of the AAA-ATPases, is found in a complex with its co-factor p47 in rat liver cytosol. Previously it had been shown that p97-mediated reassembly of Golgi cisternae from mitotic Golgi fragments requires p47 which mediates the binding of p97 to a Golgi t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment factor receptor), syntaxin 5. Here we show that it also suppresses the ATPase activity of p97 by up to 85% in a dose-dependent and saturable manner suggesting that it has other roles in the membrane fusion cycle.