Lippert, Burkhard M.; Knauer, Shirley; Fetz, Verena; Mann, Wolf; Stauber, Roland H.:
Dynamic survivin in head and neck cancer: Molecular mechanism and therapeutic potential
2007
In: International journal of cancer : IJC, Jg. 121 (2007), Heft 6, S. 1169 - 1174
Artikel/Aufsatz in Zeitschrift / Fach: Biologie
Titel:
Dynamic survivin in head and neck cancer: Molecular mechanism and therapeutic potential
Autor(in):
Lippert, Burkhard M.; Knauer, Shirley im Online-Personal- und -Vorlesungsverzeichnis LSF anzeigen; Fetz, Verena; Mann, Wolf; Stauber, Roland H.
Erscheinungsjahr
2007
Erschienen in:
International journal of cancer : IJC, Jg. 121 (2007), Heft 6, S. 1169 - 1174
ISSN
WWW URL

Abstract:

Although disease management of head and neck squamous cell carcinomas (HNSCC) has improved significantly, therapy resistance leading to tumor recurrence still counteracts improvement of long-term survival. Consequently, identification of molecular markers that signal increased risk of treatment failure or, which can be exploited by targeted therapy, is urgently needed. Survivin is strongly expressed in HNSCC, and its proposed dual role as an apoptosis inhibitor and a mitotic effector positioned survivin in the front line of cancer research. Notably, survivin is detected as a cytoplasmic and as a nuclear protein in HNSCC patients, which stimulated numerous studies to investigate and to speculate on the functional and prognostic significance of its dynamic localization. This review focuses on our current understanding of the molecular mechanisms regulating survivin's intracellular localization and discusses its potential prognostic and therapeutic relevance for head and neck cancer.