Knauer, Shirley:
Prognostic and therapeutic potential of nuclear receptors in head and neck squamous cell carcinomas.
2009
In: Journal of oncology, Heft Article ID 349205, ohne Seitenagabe
Artikel/Aufsatz in Zeitschrift2009Biologie
Titel:
Prognostic and therapeutic potential of nuclear receptors in head and neck squamous cell carcinomas.
Autor(in):
Knauer, ShirleyLSF
Erscheinungsjahr
2009
WWW URL
Erschienen in:
Titel:
Journal of oncology
in:
Heft Article ID 349205, ohne Seitenagabe

Abstract:

Head and neck squamous cell carcinomas are among the most common neoplasms worldwide and characterized by local tumor aggressiveness, high rate of early recurrences, development of metastasis, and second primary cancers. Despite modern therapeutic strategies and sophisticated surgical management, overall survival-rates remained largely unchanged over the last decades. Thus, the need for novel treatment options for this tumor entity is undeniable. A key event in carcinogenesis is the uncontrolled modulation of genetic programs. Nuclear receptors belong to a large superfamily of transcription factors implicated in a broad spectrum of physiological and pathophysiological processes, including cancer. Several nuclear receptors have also been associated with head and neck cancer. This review will summarize their mode of action, prognostic/therapeutic relevance, as well as preclinical and clinical studies currently targeting nuclear receptors in this tumor entity.