Synthesis of a TMC-95A ketomethylene analogue by cyclization via intramolecular Suzuki coupling.
In: Organic letters, Jg. 5 (2003) ; Nr. 19, S. 3435–3437
Zeitschriftenaufsatz / Fach: Biologie
A TMC-95A analogue extended at the C-terminus with NlePsi[COCH(2)]Gly-Ala-Ala-NH(2) was synthesized via side-chain cyclization of the linear precursor by a Suzuki cross-coupling reaction in solution to analyze the effect of additional P' residues on the inhibitory potency against yeast proteasome.