Musiol, Hans-Jürgen; Dong, Shouliang; Kaiser, Markus; Bausinger, Ralf; Zumbusch, Andreas; Bertsch, Uwe; Moroder, Luis:
Toward Semisynthetic Lipoproteins by Convergent Strategies Based on Click and Ligation Chemistry
2005
In: ChemBioChem : a European journal of chemical biology, Jg. 6 (2005), Heft 4, S. 625 - 628
Artikel/Aufsatz in Zeitschrift2005Biologie
Titel:
Toward Semisynthetic Lipoproteins by Convergent Strategies Based on Click and Ligation Chemistry
Autor(in):
Musiol, Hans-Jürgen; Dong, Shouliang; Kaiser, MarkusLSF; Bausinger, Ralf; Zumbusch, Andreas; Bertsch, Uwe; Moroder, Luis
Erscheinungsjahr
2005
WWW URL
Erschienen in:
Titel:
ChemBioChem : a European journal of chemical biology
in:
Jg. 6 (2005), Heft 4, S. 625 - 628
ISSN:
Signatur der UB

Abstract:

A new convergent strategy is proposed for the semisynthesis of C-terminally lipidated proteins that is based on the copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes in synthetic peptides to dimyristoylphosphatidylethanol azide followed by native chemical ligation (NCL) or expressed protein ligation (EPL) of the lipopeptide with synthetic or expressed polypeptide thioesters.