Nören-Müller, Andrea; Wilk, Wolfram; Krishna, Saxena; Schwalbe, Harald; Kaiser, Markus; Waldmann, Herbert:

Discovery of a New Class of Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B by Biology-Oriented Synthesis

In: Angewandte Chemie - International Edition, Jg. 47 (2008) ; Nr. 32, S. 5973-5977
ISSN: 0044-8249, 0570-0833, 1433-7851
Zeitschriftenaufsatz / Fach: Biologie
A biologically relevant collection: The synthesis of a macroline-derived compound collection (see general structural formula) on the basis of the criterion of biological relevance yielded an unprecedented class of inhibitors of the title mycobacterial enzyme, which is a potential target for the development of new antimycobacterial drug candidates.