Nören-Müller, Andrea; Wilk, Wolfram; Krishna, Saxena; Schwalbe, Harald; Kaiser, Markus; Waldmann, Herbert:
Discovery of a New Class of Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B by Biology-Oriented Synthesis
2008
In: Angewandte Chemie - International Edition, Jg. 47 (2008), Heft 32, S. 5973 - 5977
Artikel/Aufsatz in Zeitschrift / Fach: Biologie
Titel:
Discovery of a New Class of Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B by Biology-Oriented Synthesis
Autor(in):
Nören-Müller, Andrea; Wilk, Wolfram; Krishna, Saxena; Schwalbe, Harald; Kaiser, Markus im Online-Personal- und -Vorlesungsverzeichnis LSF anzeigen; Waldmann, Herbert
Erscheinungsjahr:
2008
Erschienen in:
Angewandte Chemie - International Edition, Jg. 47 (2008), Heft 32, S. 5973 - 5977
ISSN:
ISSN:
ISSN:
Link URL:

Abstract:

A biologically relevant collection: The synthesis of a macroline-derived compound collection (see general structural formula) on the basis of the criterion of biological relevance yielded an unprecedented class of inhibitors of the title mycobacterial enzyme, which is a potential target for the development of new antimycobacterial drug candidates.