Biology-inspired synthesis of compound libraries
In: Cellular and molecular life sciences, Jg. 65 (2008) ; 7/8, S. 1186-1201
Zeitschriftenaufsatz / Fach: Biologie
Biologically active small molecules represent the basis for chemical biology applications in which small molecules are used as chemical tools to probe biological processes. In this report, we review two approaches to design and synthesize compound libraries for biological screenings, i.e., diversity-oriented synthesis (DOS) and biology-oriented synthesis (BIOS).