Kaiser, Markus; Wetzel, Stefan; Kumar, K.; Waldmann, Herbert:
Biology-inspired synthesis of compound libraries
2008
In: Cellular and molecular life sciences, Jg. 65 (2008), Heft 7/8, S. 1186 - 1201
Artikel/Aufsatz in Zeitschrift2008Biologie
Titel:
Biology-inspired synthesis of compound libraries
Autor(in):
Kaiser, MarkusLSF; Wetzel, Stefan; Kumar, K.; Waldmann, Herbert
Erscheinungsjahr
2008
WWW URL

Abstract:

Biologically active small molecules represent the basis for chemical biology applications in which small molecules are used as chemical tools to probe biological processes. In this report, we review two approaches to design and synthesize compound libraries for biological screenings, i.e., diversity-oriented synthesis (DOS) and biology-oriented synthesis (BIOS).