Kaiser, Markus; Ottmann, Christian:

The First Small-Molecule Inhibitor of 14-3-3s: Modulating the Master Regulator

In: ChemBioChem : a European journal of chemical biology, Jg. 11 (2010) ; Nr. 15, S. 2085–2087
ISSN: 1439-4227
Zeitschriftenaufsatz / Fach: Biologie
Fakultät für Biologie
Abstract:
Adapting the adapter: The identification, synthesis and cellular activity of the first 14-3-3 protein–protein interaction inhibitor have recently been reported. This success opens up new possibilities for small-molecule modulation of the biology of these important adapter proteins with the potential for new therapeutic approaches.