Wetzel, Stefan; Wilk, Wolfram; Chammaa, Samy; Sperl, Bianca; Roth, Anke G.; Yektaoglu, Aybike; Renner, Steffen; Berg, Thorsten; Arenz, Christoph; Giannis, Athanassios; Oprea, Tudor I.; Rauh, Daniel; Kaiser, Markus; Waldmann, Herbert:

A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones

In: Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker, International edition, Jg. 49 (2010) ; Nr. 21, S. 3666–3670
ISSN: 0044-8249, 0570-0833, 1433-7851
Zeitschriftenaufsatz / Fach: Biologie
Fakultät für Biologie
Abstract:
Tactical target setting: The merging of natural product and non-natural product based hierarchical scaffold trees annotated with bioactivity (see schematic illustration) together with brachiation along structural lines of biological relevance provides a novel strategy for the prospective identification of protein targets for compound collections inspired by natural product structures.