Wetzel, Stefan; Wilk, Wolfram; Chammaa, Samy; Sperl, Bianca; Roth, Anke G.; Yektaoglu, Aybike; Renner, Steffen; Berg, Thorsten; Arenz, Christoph; Giannis, Athanassios; Oprea, Tudor I.; Rauh, Daniel; Kaiser, Markus; Waldmann, Herbert:
A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones
2010
In: Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker, International edition, Jg. 49 (2010), Heft 21, S. 3666 - 3670
Artikel/Aufsatz in Zeitschrift2010Biologie
Fakultät für Biologie
Titel:
A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones
Autor(in):
Wetzel, Stefan; Wilk, Wolfram; Chammaa, Samy; Sperl, Bianca; Roth, Anke G.; Yektaoglu, Aybike; Renner, Steffen; Berg, Thorsten; Arenz, Christoph; Giannis, Athanassios; Oprea, Tudor I.; Rauh, Daniel; Kaiser, MarkusLSF; Waldmann, Herbert
Erscheinungsjahr
2010
WWW URL
Erschienen in:
Titel:
Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker, International edition
in:
Jg. 49 (2010), Heft 21, S. 3666 - 3670
ISSN:
ISSN:
ISSN:

Abstract:

Tactical target setting: The merging of natural product and non-natural product based hierarchical scaffold trees annotated with bioactivity (see schematic illustration) together with brachiation along structural lines of biological relevance provides a novel strategy for the prospective identification of protein targets for compound collections inspired by natural product structures.