Ottmann, Christian; Hauske, Patrick; Kaiser, Markus:

Activation Instead of Inhibition: Targeting Proenzymes for Small-Molecule Intervention

In: ChemBioChem : a European journal of chemical biology, Jg. 11 (2010) ; Nr. 5, S. 637–639
ISSN: 1439-4227
Zeitschriftenaufsatz / Fach: Biologie
Fakultät für Biologie
Switching on pro-proteases: Direct small-molecule activation of proenzymes such as pro-proteases has recently be achieved for procaspase-3. This success opens up new possibilities for small-molecule intervention in biology, and reveals proenzymes as a whole new class of potential targets.

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