Ottmann, Christian; Hauske, Patrick; Kaiser, Markus:
Activation Instead of Inhibition: Targeting Proenzymes for Small-Molecule Intervention
2010
In: ChemBioChem : a European journal of chemical biology, Jg. 11 (2010), Heft 5, S. 637 - 639
Artikel/Aufsatz in Zeitschrift2010Biologie
Fakultät für Biologie
Titel:
Activation Instead of Inhibition: Targeting Proenzymes for Small-Molecule Intervention
Autor(in):
Ottmann, Christian; Hauske, PatrickLSF; Kaiser, MarkusLSF
Erscheinungsjahr
2010
WWW URL

Abstract:

Switching on pro-proteases: Direct small-molecule activation of proenzymes such as pro-proteases has recently be achieved for procaspase-3. This success opens up new possibilities for small-molecule intervention in biology, and reveals proenzymes as a whole new class of potential targets.