Clerc, Jérôme; Li, Nan; Krahn, Daniel; Groll, Michael; Bachmann, André S; Florea, Bogdan I; Overkleeft, Herman S; Kaiser, Markus:
The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity.
2011
In: Chemical communications : ChemComm, Jg. 47 (2011), Heft 1, S. 385 - 387
Artikel/Aufsatz in Zeitschrift2011Biologie
Fakultät für Biologie
Titel:
The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity.
Autor(in):
Clerc, Jérôme; Li, Nan; Krahn, DanielLSF; Groll, Michael; Bachmann, André S; Florea, Bogdan I; Overkleeft, Herman S; Kaiser, MarkusLSF
Erscheinungsjahr
2011
WWW URL

Abstract:

The preparation of a Syringolin A/Glidobactin A hybrid (SylA-GlbA) consisting of a SylA macrocycle connected to the GlbA side chain and its potent proteasome targeting of all three proteasomal subsites is reported. The influence of the syrbactin macrocycle moiety on subsite selectivity is demonstrated.