Clerc, Jérôme; Li, Nan; Krahn, Daniel; Groll, Michael; Bachmann, André S; Florea, Bogdan I; Overkleeft, Herman S; Kaiser, Markus:
The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity.
2011
In: Chemical communications : ChemComm, Jg. 47 (2011), Heft 1, S. 385 - 387
Artikel/Aufsatz in Zeitschrift / Fach: Biologie
Fakultät für Biologie
Titel:
The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity.
Autor(in):
Clerc, Jérôme; Li, Nan; Krahn, Daniel im Online-Personal- und -Vorlesungsverzeichnis LSF anzeigen; Groll, Michael; Bachmann, André S; Florea, Bogdan I; Overkleeft, Herman S; Kaiser, Markus im Online-Personal- und -Vorlesungsverzeichnis LSF anzeigen
Erscheinungsjahr
2011
Erschienen in:
Chemical communications : ChemComm, Jg. 47 (2011), Heft 1, S. 385 - 387
ISSN
ISSN
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Abstract:

The preparation of a Syringolin A/Glidobactin A hybrid (SylA-GlbA) consisting of a SylA macrocycle connected to the GlbA side chain and its potent proteasome targeting of all three proteasomal subsites is reported. The influence of the syrbactin macrocycle moiety on subsite selectivity is demonstrated.