Ehrmann, Michael; Beckwith, Jon:
Proper insertion of a complex membrane protein in the absence of its amino-terminal export signal
1991
In: Journal of Biological Chemistry, Jg. 266 (1991), Heft 25, S. 16530 - 16533
Artikel/Aufsatz in Zeitschrift / Fach: Biologie
Fakultät für Biologie
Titel:
Proper insertion of a complex membrane protein in the absence of its amino-terminal export signal
Autor(in):
Ehrmann, Michael im Online-Personal- und -Vorlesungsverzeichnis LSF anzeigen; Beckwith, Jon
Erscheinungsjahr:
1991
Erschienen in:
Journal of Biological Chemistry, Jg. 266 (1991), Heft 25, S. 16530 - 16533
ISSN:
Signatur der UB:
Link URL:

Abstract:

The MalF protein spans the Escherichia coli cytoplasmic membrane eight times. Deletion of the first transmembrane stretch of MalF, which acts as an export signal, results in a truncated protein that still exhibits high levels of maltose transport activity. These and additional results indicate that the orientation of a membrane protein is not determined by the amino-terminal export signal, topological information is distributed throughout the MalF protein, and insertion of a protein into the cytoplasmic membrane can occur nonsequentially.