Ehrmann, Michael; Beckwith, Jon:

Proper insertion of a complex membrane protein in the absence of its amino-terminal export signal

In: Journal of Biological Chemistry, Jg. 266 (1991) ; Nr. 25, S. 16530-16533
ISSN: 0021-9258
Zeitschriftenaufsatz / Fach: Biologie
ehem. Fakultät für Biologie und Geografie
Abstract:
The MalF protein spans the Escherichia coli cytoplasmic membrane eight times. Deletion of the first transmembrane stretch of MalF, which acts as an export signal, results in a truncated protein that still exhibits high levels of maltose transport activity. These and additional results indicate that the orientation of a membrane protein is not determined by the amino-terminal export signal, topological information is distributed throughout the MalF protein, and insertion of a protein into the cytoplasmic membrane can occur nonsequentially.

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