Clausen, Tim; Southan, Chris; Ehrmann, Michael:
The HtrA family of proteases: Implications for protein composition and cell fate
2002
In: Molecular Cell, Jg. 10 (2002), Heft 3, S. 443 - 455
Artikel/Aufsatz in Zeitschrift / Fach: Biologie
Fakultät für Biologie
Titel:
The HtrA family of proteases: Implications for protein composition and cell fate
Autor(in):
Clausen, Tim; Southan, Chris; Ehrmann, Michael im Online-Personal- und -Vorlesungsverzeichnis LSF anzeigen
Erscheinungsjahr:
2002
Erschienen in:
Molecular Cell, Jg. 10 (2002), Heft 3, S. 443 - 455
ISSN:
Link URL:

Abstract:

Cells precisely monitor the concentration and functionality of each protein for optimal performance. Protein quality control involves molecular chaperones, folding catalysts, and proteases that are often heat shock proteins. One quality control factor is HtrA, one of a new class of oligomeric serine proteases. The defining feature of the HtrA family is the combination of a catalytic domain with at least one C-terminal PDZ domain. Here, we discuss the properties and roles of this ATP-independent protease chaperone system in protein metabolism and cell fate.