Meltzer, Michael; Hasenbein, Sonja; Hauske, Patrick; Kucz, Nicolette; Merdanovic, Melisa; Grau, Sandra; Beil, Alexandra; Jones, Dafydd; Krojer, Tobias; Clausen, Tim; Ehrmann, Michael; Kaiser, Markus:

Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control

In: Angewandte Chemie - International Edition, Jg. 47 (2008) ; Nr. 7, S. 1332-1334
ISSN: 0044-8249, 0932-2140
Zeitschriftenaufsatz / Fach: Biologie
ehem. Fakultät für Biologie und Geografie
Unleashing the proteolytic activity of DegP: A study with synthetic mimics of cellular stress signals reveals an allosteric (chemical) activation mechanism of the bacterial HtrA protease DegP, leading to a fine-tuned amplification of protein degradation during bacterial protein quality control (see scheme: binding of a peptide sequence (circles) increases activation. The nature of the penultimate residue (red) is shown to be decisive).