Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli
; Hasenbein, Sonja; Mamant, Nicolette; Merdanovic, Melisa
; Poepsel, Simon; Hauske, Patrick
; Kaiser, Markus; Huber, Robert
; Krojer, Tobias; Clausen, Tim; Ehrmann, Michael
Research in Microbiology, Jg. 160 ; Heft 9, S. 660 - 666
Two members of the widely conserved HtrA family of serine proteases, DegP and DegS, are key players in extracytoplasmic protein quality control. The underlying mechanisms of their main functions in stress sensing, regulation and protection during the unfolded protein response are discussed.