Sonuga-Barke, Edmund J. S.; Kumsta, Robert; Schlotz, Wolff; Lasky-Su, Jessica; Marco, Rafaela; Miranda, Ana; Mulas, Fernando; Oades, Robert D.; Banaschewski, Tobias; Mulligan, Aisling; Mueller, Ueli; Andreou, Penny; Christiansen, Hanna; Gabriels, Isabel; Uebel, Henrik; Faraone, Stephen V. et al:
A Functional Variant of the Serotonin Transporter Gene (SLC6A4) Moderates Impulsive Choice in Attention-Deficit/Hyperactivity Disorder Boys and Siblings
In: Biological Psychiatry, Jg. 70 (2011), Heft 3, S. 230 - 236
2011Artikel/Aufsatz in ZeitschriftOA Grün
MedizinMedizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters
Damit verbunden: 1 Publikation(en)
Titel in Englisch:
A Functional Variant of the Serotonin Transporter Gene (SLC6A4) Moderates Impulsive Choice in Attention-Deficit/Hyperactivity Disorder Boys and Siblings
Autor*in:
Sonuga-Barke, Edmund J. S.;Kumsta, Robert;Schlotz, Wolff;Lasky-Su, Jessica;Marco, Rafaela;Miranda, Ana;Mulas, Fernando;Oades, Robert D.UDE
GND
1208788639
LSF ID
29685
ORCID
0000-0001-6151-5559ORCID iD
Sonstiges
der Hochschule zugeordnete*r Autor*in
;
Banaschewski, Tobias;Mulligan, Aisling;Mueller, Ueli;Andreou, Penny;Christiansen, Hanna;Gabriels, Isabel;Uebel, Henrik;Kuntsi, Jonna;Franke, Barbara;Buitelaar, Jan;Ebstein, Richard;Gill, Michael;Anney, Richard;Roeyers, Herbert;Rothenberger, Aribert;Sergeant, Joseph;Steinhausen, Christoph;Asherson, Philip;Faraone, Stephen V.
Erscheinungsjahr:
2011
Open Access?:
OA Grün
DuEPublico 1 ID
EVALuna Biblio ID
18680
Web of Science ID
PubMed ID
Sprache des Textes:
Englisch

Abstract in Englisch:

Background: Impulsive drive for immediate reward (IDIR) and delay aversion are dissociable elements of the preference for immediate over delayed rewards seen in attentiondeficit/ hyperactivity disorder (ADHD). We hypothesized that IDIR would be associated with dopamine regulating genes and delay aversion would be associated with serotoninregulating genes. Methods: Impulsive drive for immediate reward and delay aversion were measured in 459 male children and adolescents (328 ADHD and 131 unaffected siblings) with a laboratory choice task. The sample was genotyped for the 5HTT (SLC6A4) promoter serotonintransporter- linked polymorphic region polymorphism and a DAT1 (SLC6A3) 40-base pair variable number tandem repeat located in the 3’-untranslated region of the gene. Results: There was no effect of dopamine transporter (DAT1) on IDIR. As predicted, serotonin-transporter-linked polymorphic region s-allele carriers were more delay averse. This effect was driven by the s/l genotype in the ADHD group. These results were not altered by taking account of the rs25531 A/G single nucleotide polymorphism and were independent of age, IQ, and oppositional defiant disorder symptoms. Conclusions: The results support the genetic distinctiveness of IDIR and delay aversion in ADHD and implicate serotonin function in delay aversion. Possible explanations of the heterosis effect in the ADHD cases are presented.