Sonuga-Barke, Edmund J. S.; Kumsta, Robert; Schlotz, Wolff; Lasky-Su, Jessica; Marco, Rafaela; Miranda, Ana; Mulas, Fernando; Oades, Robert D.; Banaschewski, Tobias; Mulligan, Aisling; Mueller, Ueli; Andreou, Penny; Christiansen, Hanna; Gabriels, Isabel; Uebel, Henrik; Kuntsi, Jonna; Franke, Barbara; Buitelaar, Jan; Ebstein, Richard; Gill, Michael; Anney, Richard; Roeyers, Herbert; Rothenberger, Aribert; Sergeant, Joseph; Steinhausen, Christoph; Asherson, Philip; Faraone, Stephen V.:

A Functional Variant of the Serotonin Transporter Gene (SLC6A4) Moderates Impulsive Choice in Attention-Deficit/Hyperactivity Disorder Boys and Siblings

In: Biological Psychiatry, Jg. 70 (2011) ; Nr. 3, S. 230 - 236
Zeitschriftenaufsatz / Fach: Medizin
Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters
Abstract:
Background: Impulsive drive for immediate reward (IDIR) and delay aversion are dissociable
elements of the preference for immediate over delayed rewards seen in attentiondeficit/
hyperactivity disorder (ADHD). We hypothesized that IDIR would be associated with
dopamine regulating genes and delay aversion would be associated with serotoninregulating
genes.
Methods: Impulsive drive for immediate reward and delay aversion were measured in 459
male children and adolescents (328 ADHD and 131 unaffected siblings) with a laboratory
choice task. The sample was genotyped for the 5HTT (SLC6A4) promoter serotonintransporter-
linked polymorphic region polymorphism and a DAT1 (SLC6A3) 40-base pair
variable number tandem repeat located in the 3’-untranslated region of the gene.
Results: There was no effect of dopamine transporter (DAT1) on IDIR. As predicted,
serotonin-transporter-linked polymorphic region s-allele carriers were more delay averse.
This effect was driven by the s/l genotype in the ADHD group. These results were not altered
by taking account of the rs25531 A/G single nucleotide polymorphism and were
independent of age, IQ, and oppositional defiant disorder symptoms.
Conclusions: The results support the genetic distinctiveness of IDIR and delay aversion in
ADHD and implicate serotonin function in delay aversion. Possible explanations of the
heterosis effect in the ADHD cases are presented.

Dieser Eintrag ist freigegeben.