Meyer, Hemmo; Popp, Oliver:

Role(s) of Cdc48/p97 in mitosis

In: Biochemical Society transactions, Jg. 36 (2008) ; Part 1, S. 126-130
ISSN: 0300-5127
Zeitschriftenaufsatz / Fach: Biologie
Fakultät für Biologie » Chemische Biologie
Abstract:
The ubiquitin-dependent chaperone Cdc48 (cell divison cycle 48)/p97 is
   involved in a variety of degradative and regulatory processes during
   interphase that help to maintain cellular homoeostasis. The results
   available so far suggest that its basic activity is to mobilize
   ubiquitinated substrate proteins from cellular structures or segregate
   them from binding partners, and then hand them over for degradation or
   recycling. Several studies in different organisms show that Cdc48/p97
   also has critical roles in mitosis. However, many important aspects of
   these functions and the general perspective have remained unclear.

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