Jobs, Elmar; Wolf, Dietrich; Flyvbjerg, Henrik:

Modeling microtubule oscillations

In: Physical review letters, Jg. 79 (1997) ; Nr. 3, S. 519-522
ISSN: 1079-7114, 0031-9007
Zeitschriftenaufsatz / Fach: Physik
Synchronization of molecular reactions in a macroscopic volume may cause the volume's physical properties to change dynamically and thus reveal much about the reactions. As an example, experimental time series for so-called microtubule oscillations are analyzed in terms of a minimal model for this complex polymerization-depolymerization cycle. The model reproduces well the qualitatively different time series that result from different experimental conditions, and illuminates the role and importance of individual processes in the cycle. Simple experiments are suggested that can further test and define the model and the polymer's reaction cycle.