Fujiwara, Esther; Brand, Matthias; Borsutzky, Sabine; Steingass, Hans-P.; Markowitsch, Hans J.:

Cognitive performance of detoxified alcoholic Korsakoff syndrome patients remains stable over two years.

In: Journal of Clinical and Experimental Neuropsychology, Jg. 30 (2008) ; Nr. 5, S. 576-587
ISSN: 1380-3395
Zeitschriftenaufsatz / Fach: Angewandte Kognitionswissenschaften
Fakultät für Ingenieurwissenschaften » Informatik und Angewandte Kognitionswissenschaft
Investigated the time course of cognitive function decline in patients with chronic alcoholic Korsakoff syndrome (KS). Verbal and visual short- and long-term memory, working memory, basic executive functions, language, general knowledge, and visual spatial abilities were tested at baseline and at 2-year follow-up in 20 detoxified, chronic KS patients (6 female, mean age 59.7 years) and 20 healthy controls (9 female, mean age 59.3 years). Information on disease-related parameters, drinking history, and therapy over the 2-year study period was provided by caregivers and medical records. Compared to the control group, the majority of KS patients showed inferior cognitive functioning at both assessment occasions. No significant deterioration in cognitive functioning was observed between baseline and follow-up assessments. General knowledge, visual long-term memory, and verbal fluency slightly improved over the 2-year period. Men showed more improvement than women and better outcomes were also associated with higher premorbid education and fewer detoxifications. No evidence of accelerated cognitive decline was found over the 2-year period of observation.