Anney, R.; Hawi, Z.; Sheehan, K.; Mulligan, A.; Pinto, C.; Brookes, Keeley J.; Xu, Xiaohui; Zhou, Kaixin; Franke, Barbara; Buitelaar, Jan K.; Vermeulen, S.; Banaschewski, Tobias; Sonuga-Barke, Edmund J.S.; Ebstein, Richard; Manor, Iris; Gill, Michael et al:
Parent of origin effects in attention/deficit hyperactivity disorder (ADHD) : analysis of data from the International Multicentre ADHD Genetics (IMAGE) program
In: American Journal of Medical Genetics, Part B : Neuropsychiatric Genetics, Jg. 147B (2008), Heft 8, S. 1495 - 1500
2008Artikel/Aufsatz in ZeitschriftOA Grün
MedizinMedizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters
Damit verbunden: 1 Publikation(en)
Titel in Englisch:
Parent of origin effects in attention/deficit hyperactivity disorder (ADHD) : analysis of data from the International Multicentre ADHD Genetics (IMAGE) program
Autor*in:
Anney, R.;Hawi, Z.;Sheehan, K.;Mulligan, A.;Pinto, C.;Brookes, Keeley J.;Xu, Xiaohui;Zhou, Kaixin;Franke, Barbara;Buitelaar, Jan K.;Vermeulen, S.;Banaschewski, Tobias;Sonuga-Barke, Edmund J.S.;Ebstein, Richard;Manor, Iris;Miranda, Ana;Mulas, Fernando;Oades, Robert D.UDE
GND
1208788639
LSF ID
29685
ORCID
0000-0001-6151-5559ORCID iD
Sonstiges
der Hochschule zugeordnete*r Autor*in
;
Roeyers, Herbert;Rommelse, N.;Rothenberger, Aribert;Sergeant, Joseph A.;Steinhausen, Hans-Christoph;Taylor, Eric .A;Thompson, Margaret;Asherson, Philip;Faraone, Stephen V.;Gill, Michael
Erscheinungsjahr:
2008
Open Access?:
OA Grün
DuEPublico 1 ID
Sprache des Textes:
Englisch

Abstract:

There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested by Chi-square. There was no overall parent of origin effect in the IMAGE sample (equation image, P = 0.117). Five markers in three genes, DDC, TPH2, and SLC6A2 showed nominal association (P < 0.01) with ADHD combined subtype when restricted to maternal or paternal transmission only. Following the initial report by Hawi and co-workers three studies, including this one, found no evidence to support an overall parent of origin effect for markers associated with ADHD. We cannot however, exclude gene-specific parent of origin effect in the etiology ADHD