Xu, Xiaohui; Hawi, Ziarih; Brookes, Keeley J.; Anney, Richard J. L.; Bellgrove, M.; Franke, Barbara; Barry, E.; Chen, Wai; Kuntsi, Jonna; Banaschewski, Tobias; Buitelaar, Jan K.; Ebstein, Richard; Fitzgerald, M.; Miranda, Ana; Oades, Robert D.; Asherson, Philip et al:
Replication of a rare protective allele in the noradrenaline transporter gene and ADHD
In: American Journal of Medical Genetics, Part B : Neuropsychiatric Genetics, Jg. 147B (2008), Heft 8, S. 1564 - 1567
2008Artikel/Aufsatz in ZeitschriftOA Grün
MedizinMedizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters
Damit verbunden: 1 Publikation(en)
Titel in Englisch:
Replication of a rare protective allele in the noradrenaline transporter gene and ADHD
Autor*in:
Xu, Xiaohui;Hawi, Ziarih;Brookes, Keeley J.;Anney, Richard J. L.;Bellgrove, M.;Franke, Barbara;Barry, E.;Chen, Wai;Kuntsi, Jonna;Banaschewski, Tobias;Buitelaar, Jan K.;Ebstein, Richard;Fitzgerald, M.;Miranda, Ana;Oades, Robert D.UDE
GND
1208788639
LSF ID
29685
ORCID
0000-0001-6151-5559ORCID iD
Sonstiges
der Hochschule zugeordnete*r Autor*in
;
Roeyers, Herbert;Rothenberger, Aribert;Sergeant, Joseph A,;Sonuga- Barke, Edmund J. S.;Steinhausen, Hans-Christoph;Faraone, Stephen V.;Gill, Michael;Asherson, Philip
Erscheinungsjahr:
2008
Open Access?:
OA Grün
DuEPublico 1 ID
Sprache des Textes:
Englisch

Abstract in Englisch:

Replication is a key to resolving whether a reported genetic association represents a false positive finding or an actual genetic risk factor. In a previous study screening 51 candidate genes for association with ADHD in a multi-centre European sample (the IMAGE project), two single nucleotide polymorphisms (SNPs) within the norepinephrine transporter (SLC6A2) gene were found to be associated with attention deficit hyperactivity disorder (ADHD). The same SNP alleles were also reported to be associated with ADHD in a separate study from the Massachusetts General Hospital in the US. Using two independent samples of ADHD DSM-IV combined subtype trios we attempted to replicate the reported associations with SNPs rs11568324 and rs3785143 in SLC6A2. Significant association of the two markers was not observed in the two independent replication samples. However, across all four datasets the overall evidence of association with ADHD was significant (for SNP rs11568324 P = 0.0001; average odds ratio = 0.33; for SNP rs3785143 P  = 0.008; average odds ratio = 1.3). The data were consistent for rs11568324, suggesting the existence of a rare allele conferring protection for ADHD within the SLC6A2 gene. Further investigations should focus on identifying the mechanisms underlying the protective effect.