Heider, Dominik; Hauke, Sascha; Pyka, Martin; Kessler, Daniel:
Insights into the classification of small GTPases
2010
In: Advances and Applications in Bioinformatics and Chemistry, Band 3 (2010), S. 15 - 24
Artikel/Aufsatz in Zeitschrift / Fach: Biologie; Informatik
Titel:
Insights into the classification of small GTPases
Autor(in):
Heider, Dominik im Online-Personal- und -Vorlesungsverzeichnis LSF anzeigen; Hauke, Sascha; Pyka, Martin; Kessler, Daniel
Erscheinungsjahr:
2010
Erschienen in:
Advances and Applications in Bioinformatics and Chemistry, Band 3 (2010), S. 15 - 24
Link URL:

Abstract:

In this study we used a Random Forest-based approach for an assignment of small guanosine triphosphate proteins (GTPases) to specific subgroups. Small GTPases represent an important functional group of proteins that serve as molecular switches in a wide range of fundamental cellular processes, including intracellular transport, movement and signaling events. These proteins have further gained a special emphasis in cancer research, because within the last decades a huge variety of small GTPases from different subgroups could be related to the development of all types of tumors. Using a random forest approach, we were able to identify the most important amino acid positions for the classification process within the small GTPases superfamily and its subgroups. These positions are in line with the results of earlier studies and have been shown to be the essential elements for the different functionalities of the GTPase families. Furthermore, we provide an accurate and reliable software tool (GTPasePred) to identify potential novel GTPases and demonstrate its application to genome sequences.