Weber, Jan; Irlbacher, Horst; Ehrenhofer-Murray, Ann:
Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase
2008
In: BMC molecular biology : BioMed Central London, Jg. Vol. 9 (2008), Heft 9:100, S. 1 - 12
Artikel/Aufsatz in Zeitschrift2008BiologieChemie
Fakultät für Biologie » Genetik
Titel:
Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase
Autor(in):
Weber, JanLSF; Irlbacher, Horst; Ehrenhofer-Murray, AnnLSF
Erscheinungsjahr
2008
WWW URL
Erschienen in:
Titel:
BMC molecular biology : BioMed Central London
in:
Jg. Vol. 9 (2008), Heft 9:100, S. 1 - 12
ISSN:

Abstract:

Replication initiation at origins of replication in the yeast genome takes place on chromatin as a template, raising the question how histone modifications, for instance histone acetylation, influence origin firing. Initiation requires binding of the replication initiator, the Origin Recognition Complex (ORC), to a consensus sequence within origins. In addition, other proteins bind to recognition sites in the vicinity of ORC and support initiation. In previous work, we identified Sum1 as an origin-binding protein that contributes to efficient replication initiation. Sum1 is part of the Sum1/Rfm1/Hst1 complex that represses meiotic genes during vegetative growth via histone deacetylation by the histone deacetylase (HDAC) Hst1.