Weber, Jan; Irlbacher, Horst; Ehrenhofer-Murray, Ann:

Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase

In: BMC molecular biology : BioMed Central London, Jg. Vol. 9 (2008) ; Nr. 9:100, S. 1-12
ISSN: 1471-2199
Zeitschriftenaufsatz / Fach: Biologie; Chemie
Fakultät für Biologie » Genetik
Replication initiation at origins of replication in the yeast genome takes place on chromatin as a template, raising the question how histone modifications, for instance histone acetylation, influence origin firing. Initiation requires binding of the replication initiator, the Origin Recognition Complex (ORC), to a consensus sequence within origins. In addition, other proteins bind to recognition sites in the vicinity of ORC and support initiation. In previous work, we identified Sum1 as an origin-binding protein that contributes to efficient replication initiation. Sum1 is part of the Sum1/Rfm1/Hst1 complex that represses meiotic genes during vegetative growth via histone deacetylation by the histone deacetylase (HDAC) Hst1.