Marchfelder, Uta; Rateitschak, Katja; Ehrenhofer-Murray, Ann:
SIR-dependent repression of non-telomeric genes in Saccharomyces cerevisiae?
2003
In: Yeast : a forum for yeast researchers, Jg. 20 (2003), Heft 9, S. 797 - 801
Artikel/Aufsatz in Zeitschrift2003Chemie
Titel:
SIR-dependent repression of non-telomeric genes in Saccharomyces cerevisiae?
Autor(in):
Marchfelder, Uta; Rateitschak, Katja; Ehrenhofer-Murray, AnnLSF
Erscheinungsjahr
2003
WWW URL

Abstract:

The proteins Sir2, Sir3 and Sir4 repress transcription of the silent mating-type loci HML and HMR and of reporter genes inserted at telomeres. Previous microarray analyses suggested that additional non-telomeric genes exist which are repressed by the Sir proteins. In this study, we tested the expression of 12 such genes by Northern analysis and RT–PCR. However, we were unable to verify their SIR-dependent regulation, which suggests that SIR-mediated repression may be restricted to the known repressed regions