Oades, Robert D.; Zerbin, Dieter:

Signs of differential stimulus processing problems: a comment on event-related potentials in young schizophrenic and autistic subjects

In: Schizophrenia in Youth: Etiology and Therapeutic Consequences / Eggers, Christian (Hrsg.)
Heidelberg: Springer-Verlag (1991), S. 119 - 123
ISBN: 3-540-52485-1, 0-387-52485-1
Buchaufsatz / Kapitel / Fach: Medizin
Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters
A comparison of the Nd (negative difference ERP) in a 3-tone auditory oddball paradigm (task-minus-nontask conditions) for a 16 y-old healthy adolescent with a 16y-old patient with paranoid schizophrenia. Early (100-200 ms) and late Nd components (200-300 ms) were reduced in amplitude and shifted in topography centromedially in the patient. While we have recorded a similar impairment in schizoaffective patients, this problem was not evident in disorganised schizophrenia or OCD. Indeed, no impairment of Nd amplitude was observed in a comparison of 7 healthy children with 7 patients with childhood autism.