Büscher, Rainer:
Pathomechanisms and the diagnosis of arterial hypertension in pediatric renal allograft recipients.
2004
In: Pediatric Nephrology, Jg. 19 (2004), Heft 11, S. 1202 - 1211
Artikel/Aufsatz in Zeitschrift2004Medizin
Titel:
Pathomechanisms and the diagnosis of arterial hypertension in pediatric renal allograft recipients.
Autor(in):
Büscher, RainerLSF
Erscheinungsjahr
2004
Erschienen in:
Titel:
Pediatric Nephrology
in:
Jg. 19 (2004), Heft 11, S. 1202 - 1211

Abstract:

Arterial hypertension is common in pediatric renal allograft recipients. While the causes are multifactorial, including chronic graft rejection, immunosuppressive therapy, and renal vascular disorders, the effect of hypertension on renal allograft function is detrimental. As in adults, if not treated early and aggressively, hypertension may lead to cardiovascular damage and graft failure.Pathophysiological changes in the arteries and kidney af-ter renal transplantation and the impact of receptor regulation have not been studied extensively in children. For identifying children with hypertension following renal transplantation casual blood pressure measurements do not accurately reflect average arterial blood pressure and circadian blood pressure rhythm. Ambulatory 24-h blood pressure monitoring should regularly be applied in trans-plant patients. The purpose of this review is to analyze pathophysiological aspects of risk factors for arterial hypertension and underline the importance of regular blood pressure monitoring and early therapeutic intervention.