Imidazole derivatives. Part II. Synthesis of imidazo[1,2-a]pyridin-5-ones.
The reaction of 2-phenacylimidazole with acetylenic esters RC.tplbond.CCO2Me (R = H, CO2Me) provides imidazo[1,2-a]pyridin-5-ones I (R = same, R1 = H) by an one-pot procedure. Methylation of I (R1 = H) with CH2N2 gave N-Me derivs. I (R1 = Me). The structure of I (R = CO2Me, R1 = Me) was proved by x-ray crystallog.
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