Knoelker, Hans Joachim; Boese, Roland; Hitzemann, Rainer:

Imidazole derivatives. Part II. Synthesis of imidazo[1,2-a]pyridin-5-ones.

In: Heterocycles, Jg. 29 (1989) ; Nr. 8, S. 1551-1558
ISSN: 0385-5414
Zeitschriftenaufsatz / Fach: Chemie
The reaction of 2-phenacylimidazole with acetylenic esters RC.tplbond.CCO2Me (R = H, CO2Me) provides imidazo[1,2-a]pyridin-5-ones I (R = same, R1 = H) by an one-pot procedure. Methylation of I (R1 = H) with CH2N2 gave N-Me derivs. I (R1 = Me). The structure of I (R = CO2Me, R1 = Me) was proved by x-ray crystallog.