Mild preparation of [1-[(benzyloxy)imino]alkyl]phosphonic dichlorides: application to the synthesis of cyclic phosphonic diesters and cyclic monoester amides.
1-Benzyloxyiminophosphonates, e.g., PhCH2ON:CMeP(O)(OEt)2, were converted under very mild conditions to the corresponding phosphonyl dichlorides, e.g., PhCH2ON:CMeP(O)Cl2. The application toward the synthesis of diastereomeric 1,3,2-oxazaphospholidines and diastereomeric 1,3,2-dioxaphosphorinanes, e.g., I, is reported. The structure of I was confirmed by x-ray anal.
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