Synthesis and structure analysis of 4-quinazolone derivatives from alkyl dicyanoacetates.
Cyclocondensation of alkyl dicyanoacetate alkali salts (NC)2C:C(OR)O- M+ (R = Me, Et, Bu, M = K; R = CH2Ph, M = Na) with anthranilic acids 3,2-R1(H2N)C6H3CO2H (R1 = H, Me) gave 4-quinazolones I in 23-46% yields. The structures of I were proved by 1H and 13C NMR and NOE's by 1- and 2-dimensional methods. The structure of I (R = Et, R1 = Me) was proved by x-ray crystallog.
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