Synthesis and structure analysis of 4-quinazolone derivatives from alkyl dicyanoacetates.
In: Revue Roumaine de Chimie, Jg. 36 (1991) ; Nr. 4-7, S. 601-611
Zeitschriftenaufsatz / Fach: Chemie
Cyclocondensation of alkyl dicyanoacetate alkali salts (NC)2C:C(OR)O- M+ (R = Me, Et, Bu, M = K; R = CH2Ph, M = Na) with anthranilic acids 3,2-R1(H2N)C6H3CO2H (R1 = H, Me) gave 4-quinazolones I in 23-46% yields. The structures of I were proved by 1H and 13C NMR and NOE's by 1- and 2-dimensional methods. The structure of I (R = Et, R1 = Me) was proved by x-ray crystallog.