HLA-DR versus HLA-B5-CREG antigens in rheumatoid arthritis (RA)
In: Scand J Rheumatol (Scand.J.Rheumatol.), Jg. 16 (1987) ; Nr. 4, S. 285-289
Zeitschriftenaufsatz / Fach: Medizin
Thirty caucasian patients suffering from classic erosive rheumatoid arthritis (RA), with a condition persisting for more than 8 years, were examined together with 67 healthy control subjects with regard to associations to HLA-DR and HLA-B-CREG antigens (B5-, B8-, B12-, B16- and B27-CREG). We found a significant correlation of seropositive RA (SPRA) with HLA-DR4 (9/14 patients = 64% chi 2 = 11.8, p less than 0.05), and seronegative RA (SNRA) with B5-CREG antigens (14/16 patients = 88%, chi 2 = 7.8, p less than 0.05). This HLA locus-differing association of SPRA and SNRA could, in addition to the known differences in clinicophenomenological parameters, be additional proof of the independent entity of these two forms of illness.
Dieser Eintrag ist freigegeben.