Improved synthesis of functionalized molecular platforms related to marine cyclopeptides.
We report an improved synthesis of new mol. platforms, functionalized for studies in mol. recognition and combinatorial chem. Their structures are related to naturally occurring marine cyclopeptides such as the dolostatins and dendroamides that feature side chain functionality positioned on the same face of a rigid platform. Incorporation of Me substituted oxazole and thiazole rings into the platforms enhances the rigidity of structure and significantly improves the yields of the macrocyclization reaction in the synthesis.
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