Trimethylantimony dichloride causes genotoxic effects in Chinese hamster ovary cells after forced uptake.

In: Toxicology in Vitro, Jg. 20 (2006) ; Nr. 6, S. 1060-1065
ISSN: 0887-2333
Zeitschriftenaufsatz / Fach: Chemie
The authors demonstrate that trimethylantimony dichloride (TMSb) does not induce micronucleus (MN) formation, chromosome aberrations (CA) or sister chromatid exchanges (SCE) under normal conditions in Chinese hamster ovary (CHO-9) cells in vitro up to an applied concn. of 1 mM, nor is it significantly cytotoxic. TMSb is taken up by the cells in a dose-dependent manner, but the percentage uptake of incubation substrate is low (max 0.05%). Intracellular TMSb concn. is two-fold increased after electroporation and under these forced uptake conditions MN formation is also significantly elevated. These data indicate that resistance to TMSb in CHO-9 cells occurs at the uptake and not at the intracellular level.