Synthesis of reference substances for highly polar metabolites of nitroaromatic compounds.
In order to identify polar and hydrophilic degrdn. products of nitroarom. compds. in water and soil samples, nitroarom. compds. were prepd. and characterized as ref. stds. E.g., 4-amino-2,6-dinitrobenzyl alc. was prepd. regioselectively in 60% yield as a 19:1 mixt. with 6-amino-2,4-dinitrotoluene by redn. of 2,4,6-trinitrobenzyl alc. with Ti3+ in the presence of EDTA. Many of the newly synthesized analytes were found in various water samples from a former ammunition plant.
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