Tuning linear copolymers into protein-specific hosts.
In: Angewandte Chemie, International Edition, Jg. 45 (2006) ; Nr. 38, S. 6352-6355
Zeitschriftenaufsatz / Fach: Chemie
A new concept for selective protein recognition by artificial receptor mols. involves statistical copolymn. of simple binding monomers in defined stoichiometric ratios. As an example of its efficiency, an arginine-rich lysozyme is recognized by a bisphosphonate-rich copolymer with a remarkable Kd value of 25 nM, 100-times superior to that of cytochrome c, which is comparable in size and isoelec. point.