Koch, Sebastian J.; Renner, Christian; Xie, Xiulan; Schrader, Thomas:
Tuning linear copolymers into protein-specific hosts.
2006
In: Angewandte Chemie, International Edition, Jg. 45 (2006), Heft 38, S. 6352 - 6355
Artikel/Aufsatz in Zeitschrift / Fach: Chemie
Titel:
Tuning linear copolymers into protein-specific hosts.
Autor(in):
Koch, Sebastian J.; Renner, Christian; Xie, Xiulan; Schrader, Thomas im Online-Personal- und -Vorlesungsverzeichnis LSF anzeigen
Erscheinungsjahr
2006
Erschienen in:
Angewandte Chemie, International Edition, Jg. 45 (2006), Heft 38, S. 6352 - 6355
ISSN

Abstract:

A new concept for selective protein recognition by artificial receptor mols. involves statistical copolymn. of simple binding monomers in defined stoichiometric ratios. As an example of its efficiency, an arginine-rich lysozyme is recognized by a bisphosphonate-rich copolymer with a remarkable Kd value of 25 nM, 100-times superior to that of cytochrome c, which is comparable in size and isoelec. point.