Artificial protein sensors.
In: Molecular BioSystems, Jg. 3 (2007) ; Nr. 4, S. 241-248
Zeitschriftenaufsatz / Fach: Chemie
Protein recognition by synthetic mols. is a challenging endeavour, since these materials must bind to a large relatively flat surface domain and recognize a unique distribution of amino acid residues of varying charge, size and shape. The most promising routes involve specific metal coordination, epitope-docking on miniature proteins, aptamer selection, nonnatural peptide isosteres, functionalized platforms, secondary structure mimetics, mol. imprinting and receptors embedded in lipid layers.