Taylor, Edward C.; Dowling, James E.; Schrader, Thomas; Bhatia, Beena:
Unexpected and facile bridgehead substitution in 5,6,7,8,9,10-hexahydro-5,9-methanopyrimido[4,5-b]azocin-4(3H)-ones.
1998
In: Tetrahedron (Tetrahedron), Jg. 54 (1998), Heft 33, S. 9507 - 9518
Artikel/Aufsatz in Zeitschrift1998Chemie
Titel:
Unexpected and facile bridgehead substitution in 5,6,7,8,9,10-hexahydro-5,9-methanopyrimido[4,5-b]azocin-4(3H)-ones.
Autor(in):
Taylor, Edward C.; Dowling, James E.; Schrader, ThomasLSF; Bhatia, Beena
Erscheinungsjahr
1998

Abstract:

Condensation of 2,6-diamino-4(3H)-pyrimidinone with 2-cyclohexen-1-one gives a tricyclic product resulting from Michael addn. followed by intramol. hemiaminal formation. A methodol. was developed for reductive removal of the bridgehead hydroxyl group.