Modular building blocks for amino acid recognition in peptides.
In: Angewandte Chemie, International Edition, Jg. 41 (2002) ; Nr. 10, S. 1751-1754
Zeitschriftenaufsatz / Fach: Chemie
A toolkit of tailor-made peptide receptors contains building blocks for polar, arom., and cationic amino acids. Dipeptides are stabilized in the b-sheet conformation by complexation with an aminopyrazole which carries a U-shaped substituent with a properly placed binding site at its tip. The addnl. interaction with the amino acid side chain leads to a tenfold increase in the assocn. const.