Modular building blocks for amino acid recognition in peptides.
A toolkit of tailor-made peptide receptors contains building blocks for polar, arom., and cationic amino acids. Dipeptides are stabilized in the b-sheet conformation by complexation with an aminopyrazole which carries a U-shaped substituent with a properly placed binding site at its tip. The addnl. interaction with the amino acid side chain leads to a tenfold increase in the assocn. const.
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