Wehner, Mark; Schrader, Thomas:
Modular building blocks for amino acid recognition in peptides.
2002
In: Angewandte Chemie, International Edition, Jg. 41 (2002), Heft 10, S. 1751 - 1754
Artikel/Aufsatz in Zeitschrift2002Chemie
Titel:
Modular building blocks for amino acid recognition in peptides.
Autor(in):
Wehner, Mark; Schrader, ThomasLSF
Erscheinungsjahr
2002
Erschienen in:
Titel:
Angewandte Chemie, International Edition
in:
Jg. 41 (2002), Heft 10, S. 1751 - 1754
ISSN:

Abstract:

A toolkit of tailor-made peptide receptors contains building blocks for polar, arom., and cationic amino acids. Dipeptides are stabilized in the b-sheet conformation by complexation with an aminopyrazole which carries a U-shaped substituent with a properly placed binding site at its tip. The addnl. interaction with the amino acid side chain leads to a tenfold increase in the assocn. const.