Zadmard, Reza; Schrader, Thomas:

DNA recognition with large calixarene dimers.

In: Angewandte Chemie, International Edition, Jg. 45 (2006) ; Nr. 17, S. 2703-2706
ISSN: 1433-7851
Zeitschriftenaufsatz / Fach: Chemie
A large dimeric calix[4]arene hexaaniline binds selectively to double-stranded DNA and esp. RNA with submicromolar KD values. A simulation shows the complex between a 12-base-pair B-DNA and an anilinocalixarene dimer, which fits snugly into the major groove. Several phys. and spectroscopic characteristics strongly indicate insertion into the major groove.