Zadmard, Reza; Schrader, Thomas:
DNA recognition with large calixarene dimers.
2006
In: Angewandte Chemie, International Edition, Jg. 45 (2006), Heft 17, S. 2703 - 2706
Artikel/Aufsatz in Zeitschrift / Fach: Chemie
Titel:
DNA recognition with large calixarene dimers.
Autor(in):
Zadmard, Reza; Schrader, Thomas im Online-Personal- und -Vorlesungsverzeichnis LSF anzeigen
Erscheinungsjahr:
2006
Erschienen in:
Angewandte Chemie, International Edition, Jg. 45 (2006), Heft 17, S. 2703 - 2706
ISSN:

Abstract:

A large dimeric calix[4]arene hexaaniline binds selectively to double-stranded DNA and esp. RNA with submicromolar KD values. A simulation shows the complex between a 12-base-pair B-DNA and an anilinocalixarene dimer, which fits snugly into the major groove. Several phys. and spectroscopic characteristics strongly indicate insertion into the major groove.