DNA recognition with large calixarene dimers.
A large dimeric calixarene hexaaniline binds selectively to double-stranded DNA and esp. RNA with submicromolar KD values. A simulation shows the complex between a 12-base-pair B-DNA and an anilinocalixarene dimer, which fits snugly into the major groove. Several phys. and spectroscopic characteristics strongly indicate insertion into the major groove.
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