Action of intragastric ethanol on pancreatic exocrine secretion in relation to the interdigestive gastrointestinal motility in humans.
In: Archives Internationales de Physiologie et de Biochimie (Arch.Int.Physiol.Biochim.), Jg. 94 (1986) ; Nr. 3, S. 251-259
Zeitschriftenaufsatz / Fach: Chemie
On different days, fasted volunteers were given either 100 mL of EtOH [64-17-5] (40% vol./vol.), glucose (isocaloric to EtOH) or distd. water intragastrically; the instillations always starting during the 1st obsd. duodenal phase I of the interdigestive migrating complex (IMC). Both EtOH and glucose produced a fed pattern of motility but only glucose significantly delayed the reappearance of a new duodenal phase III of the IMC when compared to water. EtOH and glucose significantly increased the 1-h duodenal bicarbonate output 7- and 16-fold, resp. Glucose, but not EtOH, stimulated the duodenal amylase [9000-92-4] output when compared to water. Glucose, but not EtOH, caused a significant rise in plasma gastrin [9002-76-0] concn.; plasma secretin [1393-25-5] levels not being altered by both substances. Thus, in nonalcoholic humans, an intragastric administration of EtOH at a concn. present in whisky and in an amt. that is consumed in ordinary social drinking has a weak stimulatory action on pancreatic bicarbonate secretion and this action is not mediated by release of secretin.