Grunenberg, A.; Henck, J.o; Siesler, H.w.:

Theoretical derivation and practical application of energy/temperature diagrams as an instrument in preformulation studies of polymorphic drug substances.

In: International journal of pharmaceutics (Int.J.Pharm.), Jg. 129 (1996) ; Nr. 1,2, S. 147-158
ISSN: 0378-5173
Zeitschriftenaufsatz / Fach: Chemie
The construction of semiquant. energy/temp. (E/T) diagrams is discussed on the basis of thermodn. equations. An E/T diagram describes the temp. dependence of the enthalpy and the Gibbs free energy of polymorphs. Knowledge of the E/T diagram of a compd. permits the prediction of relative physicochem. values for polymorphs. Construction and interpretation of E/T diagrams is discussed with ref. to the drugs, nimodipine and acemethacin. The predicted data are compared with exptl. values.