Use of Natural Polysaccharides in Medical Textile Applications

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In this thesis chitosan and ß-cyclodextrin were used as candidates in medical textile applications. The antimicrobial activity of dissolved chitosan was evaluated quantitatively against both bacteria and fungi by different methods. The activity increased by increasing the concentration of chitosan. As a result, chitosan was applied as antimicrobial finishing agent to cotton by different anchor groups. Bacterial activity of chitosan-treated cotton was measured by tetrazolium/formazan test method. A water soluble chitosan derivative, namely carboxymethyl chitosan (CMCTS)was synthesized and characterized. CMCTS was applied to pre-cationized cotton forming ionically crosslinked cotton. The improvement in physical properties of cotton combined with a moderate antibacterial activity was achieved. In dentistry, chitosan films were applied to Molloplast® B, soft liner based material for dentures to treat the denture stomatitis. Also ß-cyclodextrin was used in pharmaceutical applications. Two antimycotic drugs were complexed by ß-cyclodextrin. The drug delivery and the solubility of the complexes were measured and evaluated by the laser nephelometry in microtiter plate in-vitro.
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Dokumententyp:
Wissenschaftliche Abschlussarbeiten » Dissertation
Fakultät / Institut:
Fakultät für Chemie
Dewey Dezimal-Klassifikation:
500 Naturwissenschaften und Mathematik » 540 Chemie
Stichwörter:
chitosan, antimicrobial, laser nephelometry, cyclodextrin, drug delivery, dentistry, textile finishing
Beitragende:
Prof. Dr. rer. nat. Schollmeyer, Eckhard [Betreuer(in), Doktorvater]
Prof. Dr. rer. nat. Tausch, Michael [Gutachter(in), Rezensent(in)]
Sprache:
Deutsch
Kollektion / Status:
Dissertationen / Dokument veröffentlicht
Datum der Promotion:
05.09.2005
Dokument erstellt am:
05.09.2005
Dateien geändert am:
23.10.2006
Medientyp:
Text