The Role of the serotonin system in ADHD: treatment implications

Dateibereich 28621

795,4 KB in einer Datei, zuletzt geändert am 13.10.2011

Dateiliste / Details

DateiDateien geändert amGröße
Serotonin_ADHD_Expert_Reviews.pdf13.10.2011 11:55:22795,4 KB
A limited number of studies have considered whether the activity of serotonin (5-HT) contributes to the problems experienced by youngsters with attention-deficit hyperactivity disorder (ADHD). The aim here is to review this work and propose interpretations. Peripheral measures of 5-HT and its metabolite do not point to a widespread association with the diagnosis. However, separate consideration of the major domains of dysfunction (motor activity, inattention and impulsivity) support a more differentiated assessment. The marked innervation of motor regions of the brain by 5-HT projections and the clear involvement of 5-HT systems in the control of locomotion in animals suggests a likely node for dysfunction in ADHD. The few relevant studies do not bear this out: but more attention should be accorded to the issue. The situation is different for attention-related processes. Here there are deficiencies in perceptual sensitivity and the appropriate designation of saliency to stimulation. These are attributable in part to altered 5-HT activity. Marked and opposite changes of 5-HT responsivity are associated with behavioral and cognitive impulsivity. There is also a growing series of studies demonstrating preferential transmission of various genetic markers for 5-HT receptors that are expressed in ADHD. Currently the heterogeneity of methods in this young discipline restricts the possibilities of definition of these markers and the types of ADHD in which they are expressed.
Permalink | Teilen/Speichern
Wissenschaftliche Texte » Artikel, Aufsatz
Fakultät / Institut:
Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters
Dewey Dezimal-Klassifikation:
600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit
Kollektion / Status:
E-Publikationen / Dokument veröffentlicht
Dateien geändert am:
Rechtliche Vermerke:
pre-publication text
Final version in: Expert Review in Neurotherapeutics, VOl. 7 (2007) ; no. 10, p. 1357-1374