A test of conditioned blocking and its development in childhood and adolescence: relationship to personality and monoamine metabolism

Dateibereich 29131

856,7 KB in einer Datei, zuletzt geändert am 19.12.2011

Dateiliste / Details

DateiDateien geändert amGröße
1996_Oades_ea_test_conditioned_complete.pdf19.12.2011 10:58:20856,7 KB
Introduction: Conditioned blocking (CB) is the undermining of conditioning to a stimulus by conjoint exposure to a stimulus already associated with the unconditioned stimulus. CB is one of several tests of "learned inattention" in which performance has been found to depend on certain features of personality and on monoamine activity recorded in animals performing CB. Methods: In part 1, the performance of 25 healthy young adults (mean age 21.6 years) on a new test form for demonstrating CB is described ("mouse-in-house"). The personality inventories used included the Hamburger neuroticism/extroversion scale (HANES) and the short version of the Minnesota multiphasic personality inventory (MMPI). From 24h urine samples collected at the time of testing the levels of four monoamine and three of their metabolites were measured as an indicator of the overall level of neurotransmitter activity. In part 2, the development of CB was studied across children and adolescents clustered into 4 age groups (means 10, 14, 17 and 22 years of age). Results: Part 1 demonstrated CB in normal healthy young adults and the expression of CB correlated with extroversion and increased catecholamine utilisation (turnover). Part 2 showed CB was least marked prepubertally, but developed across adolescence independent of IQ. Although performance did not correlate with developing personality features, like the adults, CB was positively correlated with dopamine activity. Unlike adults CB was inversely correlated with noradrenaline activity. The data show a) the development of CB in the 4 age-groups and the correlations of CB with monoamine activity, and b) how the measures of the three monoamines, their metabolites and activity (turnover) develop across age-groups. Conclusions: The maturation of attention related information processing is discussed in terms of the development and maturation of structures in the limbic part of the central nervous system and, in particular, the separate function of dopamine in switching between and noradrenaline in tuning in/out stimulus features during selection processes
Permalink | Teilen/Speichern
Wissenschaftliche Texte » Artikel, Aufsatz
Fakultät / Institut:
Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters
Dewey Dezimal-Klassifikation:
600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit » 610 Medizin und Gesundheit
Kollektion / Status:
E-Publikationen / Dokument veröffentlicht
Dateien geändert am:
In: Developmental Neuropsychology, Vol. 12 (1996) ; no. 2, p. 207 - 230 / DOI:10.1080/87565649609540647