Granule cell raphes in the developing mouse cerebellum

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deri2_Diss_Luckner.pdf16.06.2008 09:38:4931,89 MB

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Abstract.pdf16.06.2008 09:40:4738,9 KB
The cerebellar cortex of many vertebrates shows a striking parasagittal compartmentation that is thought to play a role in the establishment and maintenance of functional cerebellar connectivity. Here, I demonstrate the existence of multiple parasagittal raphes of cells in the molecular layer of the developing cerebellar cortex of postnatal mouse. The histological appearance and immunostaining profile of the raphe cells suggest that they are migrating granule cells. I therefore conclude that the granule cell raphes previously described in birds also exist in a mammalian species. The raphes in mouse are visible on nuclear stains from around birth to postnatal day 6 and are frequently found at the boundaries of Purkinje cell segments that differentially express cadherins (“early-onset” parasagittal banding pattern). A similar relation between the raphe pattern and various markers for the early-onset banding pattern has been found in the chicken cerebellum. One of the cadherins mapped in the present study (OL-protocadherin) continues to be expressed in specific Purkinje cell segments until at least postnatal day 14. At this stage of development, the borders of the OL-protocadherin-positive Purkinje cell segments coincide with the borders of Purkinje cell segments that express zebrin II, a marker for the “late-onset” parasagittal banding pattern which persists in the adult cerebellum. These findings demonstrate that the early-onset banding pattern, as reflected in the complementary arrangement of raphes/Purkinje cell segments, and the late-onset pattern of zebrin II expression share at least some positional cues during development.
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Wissenschaftliche Abschlussarbeiten » Dissertation
Fakultät / Institut:
Medizinische Fakultät » Universitätsklinikum Essen » Institut für Anatomie
Dewey Dezimal-Klassifikation:
600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit » 611 Anatomie, Zytologie, Histologie des Menschen
pattern formation, migration, Purkinje cells, cell adhesion molecules, cadherin mouse
Univ.-Prof. Dr. Büsselberg, D. [Betreuer(in), Doktorvater]
Univ.-Prof. Dr. Dr. Redies, Chr. [Gutachter(in), Rezensent(in)]
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